VKORC1 and GJB1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
9

Data Source:
BioGRID (two hybrid)

		VKORC1	GJB1
Description		vitamin K epoxide reductase complex subunit 1	gap junction protein beta 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane Lateral Plasma Membrane
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Gap Junction Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Bone Development	Cell-cell Signaling Nervous System Development Purine Ribonucleotide Transport Gap Junction Assembly Transmembrane Transport Epididymis Development
Pathways		Metabolism of vitamin K	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		94 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DCTPP1 DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24	57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6
Entrez ID		79001	2705
HPRD ID		10540	02367
Ensembl ID		ENSG00000167397	ENSG00000169562
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	A0A654ICJ7 P08034
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH	1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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