VKORC1 and CXADR

Number of citations of the paper that reports this interaction (PubMedID 21103663)
9

Data Source:
BioGRID (two hybrid)

		VKORC1	CXADR
Description		vitamin K epoxide reductase complex subunit 1	CXADR Ig-like cell adhesion molecule
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Acrosomal Vesicle Extracellular Region Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Filopodium Growth Cone Protein-containing Complex Neuron Projection Cell Body Membrane Raft
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Virus Receptor Activity Integrin Binding Protein Binding Beta-catenin Binding PDZ Domain Binding Cell Adhesion Molecule Binding Connexin Binding Cell Adhesive Protein Binding Involved In AV Node Cell-bundle Of His Cell Communication
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Bone Development	Mitochondrion Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Heart Development Germ Cell Migration Epithelial Structure Maintenance Neutrophil Chemotaxis Actin Cytoskeleton Reorganization Cell-cell Junction Organization Gamma-delta T Cell Activation Viral Entry Into Host Cell Cardiac Muscle Cell Development Transepithelial Transport AV Node Cell To Bundle Of His Cell Communication AV Node Cell-bundle Of His Cell Adhesion Involved In Cell Communication Regulation Of AV Node Cell Action Potential
Pathways		Metabolism of vitamin K	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Neutrophil count ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		94 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DCTPP1 DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24	13 interacting genes: ANKRD46 AP3B1 EWSR1 FAM3C JAML LNX1 LNX2 MAL NCOA1 NCOR1 OGT SRPK2 VKORC1
Entrez ID		79001	1525
HPRD ID		10540	11804
Ensembl ID		ENSG00000167397	ENSG00000154639
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	P78310
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH	1EAJ 1F5W 1JEW 1KAC 1P69 1P6A 1RSF 2J12 2J1K 2NPL 2W9L 2WBW 3J6L 3J6M 3J6N 3J6O
Enriched GO Terms of Interacting Partners?
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