LDLRAD4 and GET3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LDLRAD4	GET3
Description		low density lipoprotein receptor class A domain containing 4	guided entry of tail-anchored proteins factor 3, ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Nucleolus Cytoplasm GET Complex Extracellular Exosome
	Molecular Function	R-SMAD Binding	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Adverse response to drug ( 30420678) Depressive symptom improvement ( 30468137) Gut microbiota (functional units) ( 27694959) Macular thickness ( 30535121) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		3 interacting genes: GET3 SGTA ZDHHC22	41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		753	439
HPRD ID		07358	03555
Ensembl ID		ENSG00000168675	ENSG00000198356
Uniprot IDs		A0A7I2V2E6 A0A7I2V575 A8K6A9 O15165	O43681
PDB IDs			6SO5
Enriched GO Terms of Interacting Partners?
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