GET3 and VWC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GET3	VWC2
Description		guided entry of tail-anchored proteins factor 3, ATPase	von Willebrand factor C domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm GET Complex Extracellular Exosome	Basement Membrane Interstitial Matrix Extracellular Space AMPA Glutamate Receptor Complex Synapse
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport Tail-anchored Membrane Protein Insertion Into ER Membrane	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Age at first birth ( 34211149) Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF696 ZNF774 ZNF837
Entrez ID		439	375567
HPRD ID		03555	18271
Ensembl ID		ENSG00000198356	ENSG00000188730
Uniprot IDs		O43681	Q2TAL6
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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