MPPED2 and GCH1

		MPPED2	GCH1
Description		metallophosphoesterase domain containing 2	GTP cyclohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding GMP Binding Manganese Ion Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process		Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Asthma ( 27611488) Automobile speeding propensity ( 30643258) Blood urea nitrogen levels ( 29403010) Chronic kidney disease ( 22479191 26831199) Chronotype ( 30696823) Creatinine levels ( 29403010) Dental caries ( 21940522) Estimated glomerular filtration rate ( 31015462 30604766) Falling risk ( 32999390) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 27479909) Medication use (diuretics) ( 31015401) Migraine ( 27322543) Morning person ( 30696823) Pit-and-Fissure caries ( 24556642) PR interval ( 32439900) Refractive error ( 32231278) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 30993211 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		16 interacting genes: BDNF BEX4 CAGE1 FAM72A GCH1 HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 PAX6 POMP RIBC1 RXRG TRIP13 VAC14	25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ
Entrez ID		744	2643
HPRD ID		02947	02573
Ensembl ID		ENSG00000066382	ENSG00000131979
Uniprot IDs		Q15777	A0A024R642 P30793 Q8IZH9
PDB IDs			1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89
Enriched GO Terms of Interacting Partners?
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