USP1 and KLHDC2

Number of citations of the paper that reports this interaction (PubMedID 30526872)
16

Data Source:
BioGRID (unspecified method)

		USP1	KLHDC2
Description		ubiquitin specific peptidase 1	kelch domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nuclear Body Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination DNA Damage Response, Detection Of DNA Damage	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		16 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K WDR48	9 interacting genes: ATL1 EML2 ERO1A EZH2 MIS12 SELENOK SELENOS STRN4 USP1
Entrez ID		7398	23588
HPRD ID		04593	08824
Ensembl ID		ENSG00000162607	ENSG00000165516
Uniprot IDs		O94782	Q9Y2U9
PDB IDs		6DO5	6DO3 6DO4 6DO5
Enriched GO Terms of Interacting Partners?
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