KLHDC2 and MIS12

		KLHDC2	MIS12
Description		kelch domain containing 2	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane	MIS12/MIND Type Complex Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: ATL1 EML2 ERO1A EZH2 MIS12 SELENOK SELENOS STRN4 USP1	12 interacting genes: AKT1 CBX3 CBX5 DSN1 HSP90AA1 KLHDC2 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		23588	79003
HPRD ID		08824	12379
Ensembl ID		ENSG00000165516	ENSG00000167842
Uniprot IDs		Q9Y2U9	A8K1M4 Q9H081
PDB IDs		6DO3 6DO4 6DO5	5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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