UBE2G1 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 17452445)
52

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)

		UBE2G1	DIO2
Description		ubiquitin conjugating enzyme E2 G1	iodothyronine deiodinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of thyroid hormone activity
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		20 interacting genes: AMFR APP CBL CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM63 UBA1 UBE2E1 UBE3A	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		7326	1734
HPRD ID		03340	09027
Ensembl ID		ENSG00000132388	ENSG00000211448
Uniprot IDs		P62253	A8K845 Q92813
PDB IDs		2AWF 6D68
Enriched GO Terms of Interacting Partners?
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