UBE2G1 and FBXL2

Number of citations of the paper that reports this interaction (PubMedID 26037928)
61

Data Source:
BioGRID (pull down)

		UBE2G1	FBXL2
Description		ubiquitin conjugating enzyme E2 G1	F-box and leucine rich repeat protein 2
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm Membrane SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)	Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)
Interacting Genes		20 interacting genes: AMFR APP CBL CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM63 UBA1 UBE2E1 UBE3A	12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 DYNC1LI1 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1
Entrez ID		7326	25827
HPRD ID		03340	05736
Ensembl ID		ENSG00000132388	ENSG00000153558
Uniprot IDs		P62253	Q9UKC9
PDB IDs		2AWF 6D68	6O60
Enriched GO Terms of Interacting Partners?
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