DIO2 and MARCHF6

Number of citations of the paper that reports this interaction (PubMedID 19651899)
45

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		DIO2	MARCHF6
Description		iodothyronine deiodinase 2	membrane associated ring-CH-type finger 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Proteasomal Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming
Pathways		Regulation of thyroid hormone activity	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	10 interacting genes: ADGRE2 BUD31 DIO2 DNAH5 MTNR1B RGS2 TRIO UBC UBE2D2 UBE2G1
Entrez ID		1734	10299
HPRD ID		09027	11095
Ensembl ID		ENSG00000211448	ENSG00000145495
Uniprot IDs		A8K845 Q92813	O60337
PDB IDs
Enriched GO Terms of Interacting Partners?
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