DNAJC7 and NF1

Number of citations of the paper that reports this interaction (PubMedID 8836031)
11

Data Source:
HPRD (in vivo)

		DNAJC7	NF1
Description		DnaJ heat shock protein family (Hsp40) member C7	neurofibromin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Membrane Axon Dendrite
	Molecular Function	ATPase Activator Activity Protein Binding Heat Shock Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding
	Biological Process	Protein Folding Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Visual Learning Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Spinal Cord Development Forebrain Astrocyte Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Wound Healing Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Fibroblast Proliferation Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition
Pathways		Regulation of HSF1-mediated heat shock response	Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Major depressive disorder x sex interaction ( 34099189)	Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		13 interacting genes: DISC1 HSP90AA1 HUS1 MKNK1 NF1 OGT RAD1 RAD9A SMAD2 SMAD9 SMURF1 TP53 UBE4B	18 interacting genes: AKT1 APP CLK1 CRYBA1 DNAJC7 EFS EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP
Entrez ID		7266	4763
HPRD ID		07046	01203
Ensembl ID		ENSG00000168259	ENSG00000196712
Uniprot IDs		Q99615	P21359
PDB IDs			1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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