NF1 and EFS

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		NF1	EFS
Description		neurofibromin 1	embryonal Fyn-associated substrate
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Membrane Axon Dendrite	Cytoplasm Plasma Membrane Focal Adhesion
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Visual Learning Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Spinal Cord Development Forebrain Astrocyte Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Wound Healing Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Fibroblast Proliferation Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction Actin Filament Reorganization
Pathways		Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		18 interacting genes: AKT1 APP CLK1 CRYBA1 DNAJC7 EFS EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP	36 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NF1 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417
Entrez ID		4763	10278
HPRD ID		01203	09932
Ensembl ID		ENSG00000196712	ENSG00000100842
Uniprot IDs		P21359	O43281
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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