TP73 and CDK1

Number of citations of the paper that reports this interaction (PubMedID 12676926)
23

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		TP73	CDK1
Description		tumor protein p73	cyclin dependent kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin B1-CDK1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Metal Ion Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding	Virus Receptor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Kidney Development Mismatch Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Cell Cycle Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Response To Organonitrogen Compound Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Protein Phosphorylation Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Cell Aging Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Animal Organ Regeneration Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Viral Entry Into Host Cell Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs	MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib
Diseases
GWAS		Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)	Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MTHFR MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I WT1 WWOX XPO1 YAP1	188 interacting genes: ABL1 AMPH APLP2 AR ARID4A BARD1 BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN1B CDKN3 CDT1 CEP55 CEP63 CHAF1B CIITA CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EGFR EP300 EPN1 ERCC2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN GADD45A GADD45B GADD45G GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA IPO13 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PPP2R2B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RFX3 RGCC RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UBE3A UHRF2 USP16 VIM WEE1 XIAP ZBTB16
Entrez ID		7161	983
HPRD ID		03587	00302
Ensembl ID		ENSG00000078900	ENSG00000170312
Uniprot IDs		A0A0C4DFW9 A1PQX5 O15350	A0A024QZJ8 B7Z3D6 I6L9I5 P06493
PDB IDs		1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ	1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7
Enriched GO Terms of Interacting Partners?
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