TNNC1 and CDK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TNNC1	CDK1
Description		troponin C1, slow skeletal and cardiac type	cyclin dependent kinase 1
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Cardiac Troponin Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin B1-CDK1 Complex
	Molecular Function	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding	Virus Receptor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization DNA Replication DNA Repair Protein Phosphorylation Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Pronuclear Fusion Cell Aging Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Animal Organ Regeneration Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Viral Entry Into Host Cell Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Golgi Disassembly Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Striated Muscle Contraction	MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2
Drugs		Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		13 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TOPAZ1 TRIM63 UBE2C	188 interacting genes: ABL1 AMPH APLP2 AR ARID4A BARD1 BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN1B CDKN3 CDT1 CEP55 CEP63 CHAF1B CIITA CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CTNNB1 CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EGFR EP300 EPN1 ERCC2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN GADD45A GADD45B GADD45G GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA IPO13 ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PPP2R2B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RFX3 RGCC RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SRC SSBP1 STK3 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UBE3A UHRF2 USP16 VIM WEE1 XIAP ZBTB16
Entrez ID		7134	983
HPRD ID		08930	00302
Ensembl ID		ENSG00000114854	ENSG00000170312
Uniprot IDs		P63316 Q6FH91	A0A024QZJ8 B7Z3D6 I6L9I5 P06493
PDB IDs		1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI	1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7
Enriched GO Terms of Interacting Partners?
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