TBP and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 32911434)
1

Data Source:
BioGRID (two hybrid, affinity chromatography technology, fluorescent resonance energy transfer)

		TBP	NFE2L2
Description		TATA-box binding protein	nuclear factor, erythroid 2 like 2
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GO Annotations	Cellular Component	Chromatin Euchromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Protein-containing Complex Transcription Preinitiation Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding General Transcription Initiation Factor Activity DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis Positive Regulation Of Transcription, DNA-templated RNA Polymerase II Preinitiation Complex Assembly	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Aging Response To Lithium Ion Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	ROS sensing by NFE2L2 ROS sensing by NFE2L2 Regulation of HMOX1 expression and activity Heme signaling
Drugs
Diseases
GWAS		Type 1 diabetes ( 21980299)	Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		124 interacting genes: ABT1 AHR AR ATF4 BCL3 BRD2 BRF1 BRF2 BTAF1 CAND2 CEP43 CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CUEDC2 CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR2A POLR3F POU2F1 POU2F2 POU3F2 PSMC2 PSME3 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76	80 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TNNT1 TRIM24 UBE2E2 WAC ZBTB24 ZNF396
Entrez ID		6908	4780
HPRD ID		02511	02732
Ensembl ID		ENSG00000112592	ENSG00000116044
Uniprot IDs		P20226 Q32MN7	Q16236
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L	2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V
Enriched GO Terms of Interacting Partners?
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