STK4 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 15075335)
29

Data Source:
HPRD (in vivo)

		STK4	CNKSR1
Description		serine/threonine kinase 4	connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Protein Tetramerization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		Signaling by Hippo	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Bipolar disorder ( 33263727 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		29 interacting genes: AKT1 APOBEC3C CASP3 CNKSR1 CSN1S1 DAPK2 DAXX DDIT4L EMILIN3 EPPK1 H2BC21 IL2RG KEAP1 LATS1 MAFB MAP1LC3B MARK2 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 THAP12 TP53	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		6789	10256
HPRD ID		05395	11937
Ensembl ID		ENSG00000101109	ENSG00000142675
Uniprot IDs		Q13043	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT	1WWV
Enriched GO Terms of Interacting Partners?
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