CNKSR1 and MAP2K7

Number of citations of the paper that reports this interaction (PubMedID 15753034)
28

Data Source:
HPRD (in vivo)

		CNKSR1	MAP2K7
Description		connector enhancer of kinase suppressor of Ras 1	mitogen-activated protein kinase kinase 7
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Magnesium Ion Binding MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein Serine Kinase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	MAPK Cascade Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Senescence Positive Regulation Of Telomere Capping
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	33 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		10256	5609
HPRD ID		11937	04309
Ensembl ID		ENSG00000142675	ENSG00000076984
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	B4DV95 O14733
PDB IDs		1WWV	2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX
Enriched GO Terms of Interacting Partners?
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