STK4 and THAP12

Number of citations of the paper that reports this interaction (PubMedID 24255178)
195

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		STK4	THAP12
Description		serine/threonine kinase 4	THAP domain containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Protein Tetramerization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Signal Transduction Negative Regulation Of Cell Population Proliferation
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Bipolar disorder ( 33263727 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)
Interacting Genes		29 interacting genes: AKT1 APOBEC3C CASP3 CNKSR1 CSN1S1 DAPK2 DAXX DDIT4L EMILIN3 EPPK1 H2BC21 IL2RG KEAP1 LATS1 MAFB MAP1LC3B MARK2 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 THAP12 TP53	10 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 STK4 TACC1 TP53 ZNF526
Entrez ID		6789	5612
HPRD ID		05395	09567
Ensembl ID		ENSG00000101109	ENSG00000137492
Uniprot IDs		Q13043	A0A140VJQ7 O43422
PDB IDs		2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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