CNKSR1 and RHPN1

Number of citations of the paper that reports this interaction (PubMedID 14749388)
26

Data Source:
HPRD (in vitro, in vivo)

		CNKSR1	RHPN1
Description		connector enhancer of kinase suppressor of Ras 1	rhophilin Rho GTPase binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Signal Transduction
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	17 interacting genes: CALCOCO2 CEP70 CNKSR1 EFEMP2 GOLGA2 GPRASP2 HAP1 KRT15 KRT31 LZTS1 MTUS2 RHOA ROPN1 TRIM27 TRIM37 TRIM55 TRIM63
Entrez ID		10256	114822
HPRD ID		11937	17973
Ensembl ID		ENSG00000142675	ENSG00000158106
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q8TCX5
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?
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