SSTR2 and SHANK2

Number of citations of the paper that reports this interaction (PubMedID 10373412)
13

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SSTR2	SHANK2
Description		somatostatin receptor 2	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Peptide Binding Neuropeptide Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Negative Regulation Of Cell Population Proliferation Cerebellum Development Peristalsis Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		6752	22941
HPRD ID		01674	04479
Ensembl ID		ENSG00000180616	ENSG00000162105
Uniprot IDs		P30874	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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