SHANK2 and ADGRL2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
26

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SHANK2	ADGRL2
Description		SH3 and multiple ankyrin repeat domains 2	adhesion G protein-coupled receptor L2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Response To Bacterium Synapse Organization Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Cataracts ( 34127677) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476) Major depressive episode treated with electroconvulsive therapy ( 33483693)
Interacting Genes		33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	4 interacting genes: MUC1 NCK1 SHANK1 SHANK2
Entrez ID		22941	23266
HPRD ID		04479	06116
Ensembl ID		ENSG00000162105	ENSG00000117114
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	A0A6I8PTT2 O95490
PDB IDs
Enriched GO Terms of Interacting Partners?
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