SHANK2 and GMNN

		SHANK2	GMNN
Description		SH3 and multiple ankyrin repeat domains 2	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication
Pathways		Neurexins and neuroligins Neurexins and neuroligins	CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	34 interacting genes: ARNT AURKA CASP3 CCDC146 CDC20 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		22941	51053
HPRD ID		04479	06783
Ensembl ID		ENSG00000162105	ENSG00000112312
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	A0A024QZY7 O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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