SOX2 and COP1

Number of citations of the paper that reports this interaction (PubMedID 30405104)
11

Data Source:
BioGRID (enzymatic study)

		SOX2	COP1
Description		SRY-box transcription factor 2	COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2	Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related nuclear cataracts ( 33311586) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		16 interacting genes: ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 TRIM38 UBR5 XPO1	20 interacting genes: CCT4 CDKN1B CUL4B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ
Entrez ID		6657	64326
HPRD ID		08921	07455
Ensembl ID		ENSG00000181449	ENSG00000143207
Uniprot IDs		A0A0U3FYV6 P48431	Q8NHY2 X5D7N8 X5DNY7
PDB IDs		1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV	5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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