COP1 and DET1

Number of citations of the paper that reports this interaction (PubMedID 14739464)
149

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		COP1	DET1
Description		COP1 E3 ubiquitin ligase	DET1 partner of COP1 E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleus Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Menarche (age at onset) ( 25231870) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		20 interacting genes: CCT4 CDKN1B CUL4B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ	3 interacting genes: COP1 CUL4B DDB1
Entrez ID		64326	55070
HPRD ID		07455	13140
Ensembl ID		ENSG00000143207	ENSG00000140543
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	A0A024RC56 Q7L5Y6
PDB IDs		5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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