SOX2 and CDX1

Number of citations of the paper that reports this interaction (PubMedID 15143193)
29

Data Source:
BioGRID (pull down)

		SOX2	CDX1
Description		SRY-box transcription factor 2	caudal type homeobox 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of Transcription, DNA-templated Response To Wounding Anatomical Structure Morphogenesis Regulation Of Gene Expression Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Cell Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance	Regulation Of Transcription By RNA Polymerase II Embryo Development Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Somitogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Bone Morphogenesis
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age-related nuclear cataracts ( 33311586) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555) Toxoplasma gondii sag1 antibody levels ( 33204752)	Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Rectal cancer ( 33632709)
Interacting Genes		16 interacting genes: ALX4 CASP8 CDX1 COP1 FZR1 L3MBTL3 MAPK3 NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 TRIM38 UBR5 XPO1	4 interacting genes: CEBPA LEF1 PDGFRB SOX2
Entrez ID		6657	1044
HPRD ID		08921	02849
Ensembl ID		ENSG00000181449	ENSG00000113722
Uniprot IDs		A0A0U3FYV6 P48431	P47902
PDB IDs		1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV	5LUX
Enriched GO Terms of Interacting Partners?
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