COP1 and ETS2

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		COP1	ETS2
Description		COP1 E3 ubiquitin ligase	ETS proto-oncogene 2, transcription factor
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Oncogene Induced Senescence
Drugs
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		20 interacting genes: CCT4 CDKN1B CUL4B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ	22 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 HMGN1 JUN MFSD14B NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11
Entrez ID		64326	2114
HPRD ID		07455	01263
Ensembl ID		ENSG00000143207	ENSG00000157557
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	P15036
PDB IDs		5HQG 5IGQ	4BQA 4MHV
Enriched GO Terms of Interacting Partners?
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