MGAM and ARF6

		MGAM	ARF6
Description		maltase-glucoamylase	ADP ribosylation factor 6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse
	Molecular Function	Catalytic Activity Glucan 1,4-alpha-glucosidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Protein Binding Carbohydrate Binding Maltose Alpha-glucosidase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Thioesterase Binding Protein N-terminus Binding
	Biological Process	Maltose Metabolic Process Starch Catabolic Process	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Nervous System Development Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways		Digestion of dietary carbohydrate Neutrophil degranulation	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs		Acarbose Miglitol Voglibose	5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		1,5-anhydroglucitol levels ( 28588231) Anorexia nervosa ( 23568457) Blood metabolite levels ( 24816252) Idiopathic dilated cardiomyopathy ( 29495422)	Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		8 interacting genes: AQP6 ARF6 CPLX4 CREB3L1 GPR42 NCF1 SLC18A1 TMEM14B	43 interacting genes: AGAP1 ALDH5A1 AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 LSM7 MEOX2 MGAM MT2A PALS1 PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SPAG9 TOGARAM1 ZNF709
Entrez ID		8972	382
HPRD ID		01104	02714
Ensembl ID		ENSG00000257335	ENSG00000165527
Uniprot IDs		E7ER45 O43451	P62330
PDB IDs		2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU
Enriched GO Terms of Interacting Partners?
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