ST3GAL3 and VTI1A

		ST3GAL3	VTI1A
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	vesicle transport through interaction with t-SNAREs 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Golgi Membrane Endosome Autophagosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Clathrin-coated Vesicle SNARE Complex Late Endosome Membrane Trans-Golgi Network Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Neuron Projection Terminus Perinuclear Region Of Cytoplasm
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Protein Glycosylation Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide O-glycan Processing Keratan Sulfate Biosynthetic Process Viral Protein Processing Sialylation	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Fusion Autophagy Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Voluntary Musculoskeletal Movement Golgi Ribbon Formation
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness ( 30510157) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 26965516 30529582 25105248) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Evening vs. morning chronotype (sMEQ score) ( 32579418) Heel bone mineral density ( 30598549) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Lung cancer ( 23143601) Multiple sclerosis ( 23412934) Non-glioblastoma glioma ( 28346443 26424050) Non-small cell lung cancer ( 31326317) QRS duration ( 30679814 27577874 31251759 27659466) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ACTG1 CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RPL8 RRM2 SCAMP2 TGFB1I1 TTR VTI1A ZBTB5	3 interacting genes: ST3GAL3 STX16 TMBIM6
Entrez ID		6487	143187
HPRD ID		05930	18290
Ensembl ID		ENSG00000126091	ENSG00000151532
Uniprot IDs		A0A2R8Y732 Q11203	Q96AJ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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