ST3GAL3 and FBLN5

		ST3GAL3	FBLN5
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	fibulin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Protein Glycosylation Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide O-glycan Processing Keratan Sulfate Biosynthetic Process Viral Protein Processing Sialylation	Regulation Of Cell Growth Cell-matrix Adhesion Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		19 interacting genes: ACTG1 CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RPL8 RRM2 SCAMP2 TGFB1I1 TTR VTI1A ZBTB5	23 interacting genes: ATN1 GFI1B GSC HOXA1 LGMN LOXL1 LPA MEOX2 NDUFA4 NUFIP2 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		6487	10516
HPRD ID		05930	05204
Ensembl ID		ENSG00000126091	ENSG00000140092
Uniprot IDs		A0A2R8Y732 Q11203	A0A024R6G3 Q9UBX5
PDB IDs
Enriched GO Terms of Interacting Partners?
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