ST3GAL3 and HDAC5

		ST3GAL3	HDAC5
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 3	histone deacetylase 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Glycosylation Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide O-glycan Processing Keratan Sulfate Biosynthetic Process Viral Protein Processing Sialylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Belinostat Panobinostat
Diseases
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)	Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 33263727 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Mean platelet volume ( 32888494)
Interacting Genes		19 interacting genes: ACTG1 CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RPL8 RRM2 SCAMP2 TGFB1I1 TTR VTI1A ZBTB5	69 interacting genes: ADGRB2 ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 GOSR2 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 PSME3 RFXANK RUNX3 SFN SGCA SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SPARC ST3GAL3 SUV39H1 TAB2 UBC UBE2I UTP18 VAT1 YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		6487	10014
HPRD ID		05930	09246
Ensembl ID		ENSG00000126091	ENSG00000108840
Uniprot IDs		A0A2R8Y732 Q11203	Q9UQL6
PDB IDs			5UWI
Enriched GO Terms of Interacting Partners?
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