SCG5 and NR1H2

Number of citations of the paper that reports this interaction (PubMedID 15604093)
56

Data Source:
BioGRID (two hybrid)

		SCG5	NR1H2
Description		secretogranin V	nuclear receptor subfamily 1 group H member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Secretory Granule	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Binding Enzyme Regulator Activity Unfolded Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding
	Biological Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways			PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs			GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS		Body shape index ( 34021172) Chin dimples ( 27182965) Colorectal cancer ( 25990418 30529582 21761138 24737748 31826910) Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: AGTR1 CCR2 FBXL17 KHDRBS1 MEOX2 NR1H2 PCSK2 UBQLN1 UBQLN2 UBQLN4	51 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		6447	7376
HPRD ID		01410	02660
Ensembl ID		ENSG00000166922	ENSG00000131408
Uniprot IDs		A0A024R9I1 P05408	F1D8P7 P55055
PDB IDs			1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?
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