SCG5 and FBXL17

Number of citations of the paper that reports this interaction (PubMedID 31560077)
2

Data Source:
BioGRID (two hybrid)

		SCG5	FBXL17
Description		secretogranin V	F-box and leucine rich repeat protein 17
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Secretory Granule	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Binding Enzyme Regulator Activity Unfolded Protein Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle
Pathways			Regulation of BACH1 activity
Drugs
Diseases
GWAS		Body shape index ( 34021172) Chin dimples ( 27182965) Colorectal cancer ( 25990418 30529582 21761138 24737748 31826910) Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) smoking initiation in schizophrenia ( 33691233) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)
Interacting Genes		10 interacting genes: AGTR1 CCR2 FBXL17 KHDRBS1 MEOX2 NR1H2 PCSK2 UBQLN1 UBQLN2 UBQLN4	39 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KEAP1 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 USP25 ZMYM2 ZNF350
Entrez ID		6447	64839
HPRD ID		01410	10950
Ensembl ID		ENSG00000166922	ENSG00000145743
Uniprot IDs		A0A024R9I1 P05408	Q9UF56
PDB IDs			6W66 6WCQ
Enriched GO Terms of Interacting Partners?
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