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NR1H2 and RARA
Number of citations of the paper that reports this interaction (PubMedID
15604093
)
56
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
NR1H2
RARA
Description
nuclear receptor subfamily 1 group H member 2
retinoic acid receptor alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell Surface
Actin Cytoskeleton
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Apolipoprotein A-I Receptor Binding
Retinoid X Receptor Binding
ATPase Binding
Translation Repressor Activity, MRNA Regulatory Element Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Retinoic Acid-responsive Element Binding
MRNA 5'-UTR Binding
Protein Kinase A Binding
Alpha-actinin Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Pinocytosis
Positive Regulation Of Lipoprotein Lipase Activity
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of High-density Lipoprotein Particle Assembly
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Neural Tube Closure
Liver Development
Glandular Epithelial Cell Development
Growth Plate Cartilage Development
Protein Phosphorylation
Signal Transduction
Germ Cell Development
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Negative Regulation Of Translation
Hippocampus Development
Cell Differentiation
Prostate Gland Development
Negative Regulation Of Granulocyte Differentiation
Embryonic Camera-type Eye Development
Regulation Of Myelination
Response To Estradiol
Response To Retinoic Acid
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Response To Vitamin A
Response To Cytokine
Multicellular Organism Growth
Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Response To Ethanol
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Ventricular Cardiac Muscle Cell Differentiation
Sertoli Cell Fate Commitment
Limb Development
Face Development
Trachea Cartilage Development
Chondroblast Differentiation
Negative Regulation Of Cartilage Development
Cellular Response To Lipopolysaccharide
Cellular Response To Estrogen Stimulus
Pathways
PPARA activates gene expression
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
GW-3965
Benzenesulfinic acid
TO-901317
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diacerein
Rhein
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Trifarotene
Diseases
GWAS
Asthma (
31619474
)
Interacting Genes
51 interacting genes:
BAG6
CDKN1A
CHD3
COL4A5
CSAD
DNMT3L
DUSP12
ERG28
FAF1
FOXO3
HDAC4
HMGXB4
ING3
KDM1A
LAMC3
MDFI
MED1
MPP1
NCOA1
NCOA3
NCOA6
NCOR1
NCOR2
NPY
NR0B2
NRIP1
PCDH17
PPARA
PPARD
PPARG
PRKCA
RARA
RHOU
RMI1
ROBO2
RXRA
RXRB
RXRG
SCG5
SIRT1
SMPD1
SORBS2
SPRY2
SUV39H1
TMEM161A
UBE2D1
UBE2I
VDR
VIM
YY1
ZXDC
98 interacting genes:
ACTN4
AKT1
ALOX15B
ALX1
ARID1A
ARID5A
ARNTL
BAG1
BBS4
BTG1
CCND3
CCNDBP1
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MCRS1
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2C1
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PLEKHF2
PML
PNRC2
POU2F1
PPARG
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIB3
TRIM24
TRIP4
TUBG1
UBE3A
UBQLN1
USP7
ZBTB16
Entrez ID
7376
5914
HPRD ID
02660
06769
Ensembl ID
ENSG00000131408
ENSG00000131759
Uniprot IDs
F1D8P7
P55055
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
PDB IDs
1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
4NQA
4RAK
5HJP
5I4V
5JY3
5KYA
5KYJ
6JIO
6K9G
6K9H
6K9M
6S4N
6S4T
6S4U
6S5K
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
6XWG
Enriched GO Terms of Interacting Partners
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