SCG5 and PCSK2

Number of citations of the paper that reports this interaction (PubMedID 11439082)
50

Data Source:
HPRD (in vitro, in vivo)

		SCG5	PCSK2
Description		secretogranin V	proprotein convertase subtilisin/kexin type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Secretory Granule	Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Dendrite Neuron Projection Perikaryon Intracellular Membrane-bounded Organelle
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Binding Enzyme Regulator Activity Unfolded Protein Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing
Pathways			Insulin processing
Drugs			Insulin pork
Diseases
GWAS		Body shape index ( 34021172) Chin dimples ( 27182965) Colorectal cancer ( 25990418 30529582 21761138 24737748 31826910) Obesity-related traits ( 23251661) Waist circumference adjusted for body mass index ( 34021172)	Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		10 interacting genes: AGTR1 CCR2 FBXL17 KHDRBS1 MEOX2 NR1H2 PCSK2 UBQLN1 UBQLN2 UBQLN4	3 interacting genes: IAPP PMCH SCG5
Entrez ID		6447	5126
HPRD ID		01410	01202
Ensembl ID		ENSG00000166922	ENSG00000125851
Uniprot IDs		A0A024R9I1 P05408	P16519
PDB IDs
Enriched GO Terms of Interacting Partners?
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