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RPA1 and TK1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
136
Data Source:
BioGRID
(two hybrid)
RPA1
TK1
Description
replication protein A1
thymidine kinase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of DNA Damage
Cytosol
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Single-stranded Telomeric DNA Binding
Metal Ion Binding
G-rich Strand Telomeric DNA Binding
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA-dependent DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Protein Localization To Chromosome
Meiotic Cell Cycle
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Phosphorylation
Thymidine Metabolic Process
Protein Homotetramerization
DNA Biosynthetic Process
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
G1/S-Specific Transcription
Pyrimidine salvage
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
Diseases
GWAS
Airway imaging phenotypes (
26030696
)
Bipolar disorder (
31043756
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Interacting Genes
68 interacting genes:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CPE
CSNK2B
DMC1
EHMT2
ERCC1
ERCC4
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HSPA6
HUS1
MCM2
MCM4
MCM6
MCM7
MMS22L
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRIMPOL
PRKDC
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RFWD3
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SEM1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
ZBTB14
163 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC115
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DCAF7
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UNC119
UPF2
USP4
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
6117
7083
HPRD ID
01565
01771
Ensembl ID
ENSG00000132383
ENSG00000167900
Uniprot IDs
P27694
A0A384MDV9
K7ES52
P04183
PDB IDs
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
4LUO
4LUV
4LUZ
4LW1
4LWC
4NB3
4O0A
4R4C
4R4I
4R4O
4R4Q
4R4T
5E7N
5EAY
5N85
5N8A
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
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