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RPA1 and ANXA1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
136
Data Source:
BioGRID
(two hybrid)
RPA1
ANXA1
Description
replication protein A1
annexin A1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of DNA Damage
Cornified Envelope
Phagocytic Cup
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Extrinsic Component Of Membrane
Extrinsic Component Of External Side Of Plasma Membrane
Extrinsic Component Of Endosome Membrane
Motile Cilium
Early Endosome Membrane
Mitochondrial Membrane
Vesicle
Protein-containing Complex
Sarcolemma
Mast Cell Granule
Collagen-containing Extracellular Matrix
Extracellular Exosome
Synaptic Membrane
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Single-stranded Telomeric DNA Binding
Metal Ion Binding
G-rich Strand Telomeric DNA Binding
Single-stranded DNA Binding
Single-stranded RNA Binding
Signaling Receptor Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Phospholipase A2 Inhibitor Activity
Double-stranded DNA Helicase Activity
Identical Protein Binding
Calcium-dependent Protein Binding
Cadherin Binding Involved In Cell-cell Adhesion
DNA/DNA Annealing Activity
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA-dependent DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Protein Localization To Chromosome
Meiotic Cell Cycle
Neutrophil Homeostasis
Adaptive Immune Response
Monocyte Chemotaxis
Regulation Of Leukocyte Migration
Phagocytosis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Response To X-ray
Myoblast Migration Involved In Skeletal Muscle Regeneration
Peptide Cross-linking
Insulin Secretion
Keratinocyte Differentiation
Prostate Gland Development
Endocrine Pancreas Development
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Prostaglandin Biosynthetic Process
Actin Cytoskeleton Reorganization
Response To Estradiol
DNA Duplex Unwinding
Regulation Of Interleukin-1 Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Neutrophil Apoptotic Process
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Gliogenesis
Positive Regulation Of T Cell Proliferation
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Estrous Cycle
Innate Immune Response
Positive Regulation Of T-helper 1 Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Exocytosis
Alpha-beta T Cell Differentiation
Regulation Of Hormone Secretion
Arachidonic Acid Secretion
Negative Regulation Of Protein Secretion
Regulation Of Inflammatory Response
Cellular Response To Hydrogen Peroxide
Hepatocyte Differentiation
Prolactin Secretion
Response To Interleukin-1
Cellular Response To Glucocorticoid Stimulus
Granulocyte Chemotaxis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cell-cell Adhesion
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Phospholipase A2 Activity
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Smooth Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Drugs
Amcinonide
Fluocinolone acetonide
Hydrocortisone
Methylprednisolone
Clobetasol propionate
Budesonide
Dexamethasone
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Diseases
GWAS
Airway imaging phenotypes (
26030696
)
Bipolar disorder (
31043756
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Blood protein levels (
28240269
)
Chronotype (
30696823
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Metabolite levels (
23823483
)
Parkinson's disease (
26227905
)
Schizophrenia, bipolar disorder and depression (combined) (
20713499
)
Urate levels in obese individuals (
25811787
)
Interacting Genes
68 interacting genes:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CPE
CSNK2B
DMC1
EHMT2
ERCC1
ERCC4
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HSPA6
HUS1
MCM2
MCM4
MCM6
MCM7
MMS22L
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRIMPOL
PRKDC
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RFWD3
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SEM1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
ZBTB14
35 interacting genes:
APBB1
CCT7
COPS6
CSAD
CZIB
DYSF
EGFR
EPHA2
ERG28
FAF1
FPR1
GAPDH
HMGA1
HSPB1
KLHL23
KMT2B
KRT8
LNPK
LRIF1
MEIS2
OTUB1
PRKCI
RPA1
S100A11
SRC
SUMO2
TGM2
TRPM7
UBE2D1
UBE2I
UBE3A
UCHL5
UNC119
USP7
YWHAQ
Entrez ID
6117
301
HPRD ID
01565
01060
Ensembl ID
ENSG00000132383
ENSG00000135046
Uniprot IDs
P27694
P04083
Q5TZZ9
PDB IDs
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
4LUO
4LUV
4LUZ
4LW1
4LWC
4NB3
4O0A
4R4C
4R4I
4R4O
4R4Q
4R4T
5E7N
5EAY
5N85
5N8A
1AIN
1BO9
1QLS
5VFW
Enriched GO Terms of Interacting Partners
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