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RPA1 and TREX1
Number of citations of the paper that reports this interaction (PubMedID
12791985
)
1148
Data Source:
HPRD
(in vitro)
RPA1
TREX1
Description
replication protein A1
three prime repair exonuclease 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of DNA Damage
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Protein-DNA Complex
Nuclear Replication Fork
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Single-stranded Telomeric DNA Binding
Metal Ion Binding
G-rich Strand Telomeric DNA Binding
Magnesium Ion Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
3'-5'-exodeoxyribonuclease Activity
DNA Binding, Bending
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA-dependent DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Protein Localization To Chromosome
Meiotic Cell Cycle
DNA Catabolic Process, Exonucleolytic
Blood Vessel Development
Kidney Development
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Recombination
Determination Of Adult Lifespan
Regulation Of Fatty Acid Metabolic Process
Mitotic G1 DNA Damage Checkpoint Signaling
Transposition, RNA-mediated
Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Cellular Response To Interferon-beta
CD86 Biosynthetic Process
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Establishment Of Protein Localization
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Regulation Of Catalytic Activity
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Immune Complex Formation
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Regulation by TREX1
IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS
Airway imaging phenotypes (
26030696
)
Bipolar disorder (
31043756
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
68 interacting genes:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CPE
CSNK2B
DMC1
EHMT2
ERCC1
ERCC4
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HSPA6
HUS1
MCM2
MCM4
MCM6
MCM7
MMS22L
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRIMPOL
PRKDC
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RFWD3
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SEM1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
ZBTB14
46 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
FAM174A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MFSD14B
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
Entrez ID
6117
11277
HPRD ID
01565
09423
Ensembl ID
ENSG00000132383
ENSG00000213689
Uniprot IDs
P27694
Q5TZT0
Q9NSU2
PDB IDs
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
4LUO
4LUV
4LUZ
4LW1
4LWC
4NB3
4O0A
4R4C
4R4I
4R4O
4R4Q
4R4T
5E7N
5EAY
5N85
5N8A
Enriched GO Terms of Interacting Partners
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