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TK1 and CDKN1A
Number of citations of the paper that reports this interaction (PubMedID
11389691
)
5
Data Source:
HPRD
(in vitro, in vivo)
TK1
CDKN1A
Description
thymidine kinase 1
cyclin dependent kinase inhibitor 1A
Image
GO Annotations
Cellular Component
Cytosol
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Protein-containing Complex
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Molecular Function
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Sequestering Activity
Biological Process
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Phosphorylation
Thymidine Metabolic Process
Protein Homotetramerization
DNA Biosynthetic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Import Into Nucleus
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Wound Healing
Tissue Regeneration
Negative Regulation Of Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Positive Regulation Of Fibroblast Proliferation
Response To Corticosterone
Regulation Of Cell Cycle
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
G1/S-Specific Transcription
Pyrimidine salvage
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
Arsenic trioxide
Diseases
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
33547301
34315874
)
Aspartate aminotransferase levels (
33547301
34315874
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
22634755
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495596
33495597
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
Ischemic stroke (
29531354
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
31217584
21076409
27659466
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
163 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC115
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DCAF7
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UNC119
UPF2
USP4
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
206 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK12
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
PTK7
QARS1
RAB1A
RACK1
RAI1
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SKP2
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TRAF1
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP11
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
7083
1026
HPRD ID
01771
00298
Ensembl ID
ENSG00000167900
ENSG00000124762
Uniprot IDs
A0A384MDV9
K7ES52
P04183
A0A024RCX5
P38936
PDB IDs
1W4R
1XBT
2ORV
2WVJ
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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