ANXA1 and FAF1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		ANXA1	FAF1
Description		annexin A1	Fas associated factor 1
Image
GO Annotations	Cellular Component	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extrinsic Component Of Membrane Extrinsic Component Of External Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Motile Cilium Early Endosome Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Sarcolemma Mast Cell Granule Collagen-containing Extracellular Matrix Extracellular Exosome Synaptic Membrane	Nucleus Nuclear Envelope Nucleoplasm Cytosol CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Double-stranded DNA Helicase Activity Identical Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion DNA/DNA Annealing Activity	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Neutrophil Homeostasis Adaptive Immune Response Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Response To Xenobiotic Stimulus Response To X-ray Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Actin Cytoskeleton Reorganization Response To Estradiol DNA Duplex Unwinding Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Gliogenesis Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Response To Peptide Hormone Estrous Cycle Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling
Drugs		Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate
Diseases
GWAS		Blood protein levels ( 28240269) Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical volume ( 32963231) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)	Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Left ventricle wall thickness ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993 31194737) Neutrophil percentage of white cells ( 32888494) Pancreas fat ( 34128465) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 27841878 30578418) QRS duration ( 30679814 21076409) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30297969 26818947 32499647 30718926 28869590) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		35 interacting genes: APBB1 CCT7 COPS6 CSAD CZIB DYSF EGFR EPHA2 ERG28 FAF1 FPR1 GAPDH HMGA1 HSPB1 KLHL23 KMT2B KRT8 LNPK LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC SUMO2 TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 USP7 YWHAQ	46 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD XIAP YTHDF3
Entrez ID		301	11124
HPRD ID		01060	05124
Ensembl ID		ENSG00000135046	ENSG00000185104
Uniprot IDs		P04083 Q5TZZ9	Q9UNN5
PDB IDs		1AIN 1BO9 1QLS 5VFW	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?
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