TREX1 and CYB561

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TREX1	CYB561
Description		three prime repair exonuclease 1	cytochrome b561
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Protein-DNA Complex Nuclear Replication Fork	Lysosomal Membrane Integral Component Of Membrane Chromaffin Granule Membrane
	Molecular Function	Magnesium Ion Binding Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity DNA Binding, Bending 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding	Protein Binding Oxidoreductase Activity Metal Ion Binding Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic Blood Vessel Development Kidney Development Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Recombination Determination Of Adult Lifespan Regulation Of Fatty Acid Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Transposition, RNA-mediated Regulation Of Type I Interferon Production DNA Duplex Unwinding Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Interferon-beta CD86 Biosynthetic Process Apoptotic Cell Clearance Regulation Of Cellular Respiration Establishment Of Protein Localization Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Regulation Of Catalytic Activity Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization	Cellular Iron Ion Homeostasis Electron Transport Chain Ascorbate Homeostasis
Pathways		Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28739976)
Interacting Genes		46 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 FAM174A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MFSD14B MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1	60 interacting genes: ANKRD46 AQP6 BEST2 BET1 BIK BNIP1 CD79A CDIPT CLDN9 CMTM2 CREB3 DARS2 EBP EDA EFNA5 EHHADH ERG28 ERGIC3 FKBP8 GGT7 GIMAP5 GOSR2 GPR152 GPX8 HMOX1 LHFPL5 LMNA LPAR3 NCOA1 OPRM1 ORMDL2 PLP2 REEP6 RNF5 SCD SEC22A SERP2 SLC19A3 SLC35C2 SLC38A7 SLC39A1 SLC39A2 SMIM1 SSMEM1 STX3 SYNJ2BP TM4SF18 TMEM11 TMEM128 TMEM14B TMEM179B TMEM242 TMEM65 TMPPE TREX1 TSNARE1 UBE2J1 VAPA VAPB ZDHHC7
Entrez ID		11277	1534
HPRD ID		09423	02485
Ensembl ID		ENSG00000213689	ENSG00000008283
Uniprot IDs		Q5TZT0 Q9NSU2	B3KTA1 J3QRH5 P49447
PDB IDs
Enriched GO Terms of Interacting Partners?
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