RIT1 and RGL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RIT1	RGL3
Description		Ras like without CAAX 1	ral guanine nucleotide dissociation stimulator like 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Cytosol
	Molecular Function	GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Signalling to p38 via RIT and RIN	RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447 27618448) Hypertension ( 31879980 32709000 27618447 27618448) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 27618447 27618448 30578418)
Interacting Genes		17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2
Entrez ID		6016	57139
HPRD ID		10195	18844
Ensembl ID		ENSG00000143622	ENSG00000205517
Uniprot IDs		Q92963	A0A0A0MRX4 Q3MIN7
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?