RIT1 and RGL1

Number of citations of the paper that reports this interaction (PubMedID 10545207)
27

Data Source:
HPRD (in vitro)

		RIT1	RGL1
Description		Ras like without CAAX 1	ral guanine nucleotide dissociation stimulator like 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Cellular_component Cytosol
	Molecular Function	GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity
Pathways		Signalling to p38 via RIT and RIN	PPARA activates gene expression RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Immature fraction of reticulocytes ( 32888494) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Retinal detachment or retinal break ( 31816047)
Interacting Genes		17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	5 interacting genes: APP HRAS RAP2A RIT1 RIT2
Entrez ID		6016	23179
HPRD ID		10195	12032
Ensembl ID		ENSG00000143622	ENSG00000143344
Uniprot IDs		Q92963	B7Z2W5 B7Z915 B7ZB61 Q9NZL6
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?
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