RGL3 and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RGL3	RRAS2
Description		ral guanine nucleotide dissociation stimulator like 3	RAS related 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways		RAF/MAP kinase cascade	RND1 GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447 27618448) Hypertension ( 31879980 32709000 27618447 27618448) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 27618447 27618448 30578418)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2	32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		57139	22800
HPRD ID		18844	02518
Ensembl ID		ENSG00000205517	ENSG00000133818
Uniprot IDs		A0A0A0MRX4 Q3MIN7	P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?
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