RGL3 and RIT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RGL3	RIT2
Description		ral guanine nucleotide dissociation stimulator like 3	Ras like without CAAX 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity	MAPK Cascade Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling
Pathways		RAF/MAP kinase cascade	Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447 27618448) Hypertension ( 31879980 32709000 27618447 27618448) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 27618447 27618448 30578418)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 32201043 27182965 21738487 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2	13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2
Entrez ID		57139	6014
HPRD ID		18844	15253
Ensembl ID		ENSG00000205517	ENSG00000152214
Uniprot IDs		A0A0A0MRX4 Q3MIN7	Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?
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