RECQL and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 9168958)
30

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		RECQL	KPNA4
Description		RecQ like helicase	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane	Nucleus Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity 3'-5' DNA Helicase Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding	NLS-bearing Protein Import Into Nucleus
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: KPNA2 KPNA4 MARK3 NKX2-2 PLEKHA5 RPA1 UBC	27 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NFE2L2 NTRK3 NUP50 OGT PLAA RAC1 RCC1 RECQL TGM2 WT1
Entrez ID		5965	3840
HPRD ID		02762	04275
Ensembl ID		ENSG00000004700	ENSG00000186432
Uniprot IDs		A0A024RAV2 P46063	O00629
PDB IDs		2V1X 2WWY 4U7D 6JTZ	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL
Enriched GO Terms of Interacting Partners?
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