RECQL and NKX2-2

		RECQL	NKX2-2
Description		RecQ like helicase	NK2 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity 3'-5' DNA Helicase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: KPNA2 KPNA4 MARK3 NKX2-2 PLEKHA5 RPA1 UBC	7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1
Entrez ID		5965	4821
HPRD ID		02762	05213
Ensembl ID		ENSG00000004700	ENSG00000125820
Uniprot IDs		A0A024RAV2 P46063	O95096
PDB IDs		2V1X 2WWY 4U7D 6JTZ
Enriched GO Terms of Interacting Partners?
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