RAP1GAP and CSNK1G2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RAP1GAP	CSNK1G2
Description		RAP1 GTPase activating protein	casein kinase 1 gamma 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Early Endosome Cytosol Membrane Axon Dendrite Neuronal Cell Body	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly Negative Regulation Of GTP Binding Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Rap1 signalling RET signaling	Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs			IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Body mass index ( 25673413) Coronary artery disease ( 29212778) Periodontitis (stage III/IV grade C) ( 33745150) Red cell distribution width ( 32888494 27863252)
Interacting Genes		16 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A SDHB ZBTB12	15 interacting genes: APP APPBP2 CERT1 DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 OGT PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 WDCP
Entrez ID		5909	1455
HPRD ID		02609	03738
Ensembl ID		ENSG00000076864	ENSG00000133275
Uniprot IDs		A0A024RAB5 P47736 X6R8W7	P78368
PDB IDs		1SRQ 3BRW	2C47
Enriched GO Terms of Interacting Partners?
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