CSNK1G2 and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		CSNK1G2	RAP1GAP
Description		casein kinase 1 gamma 2	RAP1 GTPase activating protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane	Golgi Membrane Cytoplasm Early Endosome Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway	Adaptive Immune Response Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly Negative Regulation Of GTP Binding Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways		Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane	Rap1 signalling RET signaling
Drugs		IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Body mass index ( 25673413) Coronary artery disease ( 29212778) Periodontitis (stage III/IV grade C) ( 33745150) Red cell distribution width ( 32888494 27863252)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		15 interacting genes: APP APPBP2 CERT1 DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 OGT PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 WDCP	16 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A SDHB ZBTB12
Entrez ID		1455	5909
HPRD ID		03738	02609
Ensembl ID		ENSG00000133275	ENSG00000076864
Uniprot IDs		P78368	A0A024RAB5 P47736 X6R8W7
PDB IDs		2C47	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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