RAP1GAP and ZBTB12

Number of citations of the paper that reports this interaction (PubMedID 8939933)
11

Data Source:
HPRD (in vitro, two hybrid)

		RAP1GAP	ZBTB12
Description		RAP1 GTPase activating protein	zinc finger and BTB domain containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Early Endosome Cytosol Membrane Axon Dendrite Neuronal Cell Body	Nucleoplasm
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Adaptive Immune Response Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly Negative Regulation Of GTP Binding Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Clostridioides difficle infection ( 33841421) Clostridioides difficle infection in antibiotics-users ( 33841421) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A SDHB ZBTB12	5 interacting genes: GRB2 HRAS NCK2 RAP1GAP ZBTB26
Entrez ID		5909	221527
HPRD ID		02609	15691
Ensembl ID		ENSG00000076864	ENSG00000204366
Uniprot IDs		A0A024RAB5 P47736 X6R8W7	Q9Y330
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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