MRAS and RAPGEF6

Number of citations of the paper that reports this interaction (PubMedID 11524421)
21

Data Source:
HPRD (in vivo, in vitro)

		MRAS	RAPGEF6
Description		muscle RAS oncogene homolog	Rap guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		22808	51735
HPRD ID		06662	11483
Ensembl ID		ENSG00000158186	ENSG00000158987
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	B2RTU6 Q8TEU7
PDB IDs			2D93 3LNY
Enriched GO Terms of Interacting Partners?
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